|Flow Cytometry (Flow)||1:10-1:50|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 51-79 amino acids from the N-terminal region of human CHMP4B|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with chicken, mouse, Xenopus and zebrafish based on sequence homology.
CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C20orf178; Charged multivesicular body protein 4b; CHMP4A; CHMP4b; chromatin modifying protein 4B; Chromatin-modifying protein 4b; CTPP3; dJ553F4.4; hSnf7-2; hVps32-2; Shax1; SNF7; SNF7 homolog associated with Alix 1; Snf7 homologue associated with Alix 1; SNF7-2; vacuolar prote; Vacuolar protein sorting-associated protein 32-2; vacuolar protein-sorting-associated protein 32-2; Vps32-2; VPS32B
Gene Aliases: C20orf178; CHMP4A; CHMP4B; CTPP3; CTRCT31; dJ553F4.4; SHAX1; SNF7; SNF7-2; Vps32-2; VPS32B
UniProt ID: (Human) Q9H444
Entrez Gene ID: (Human) 128866
Molecular Function: transfer/carrier protein
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