Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses).
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Protein Aliases: Charged multivesicular body protein 4b; Charged multivesicular body protein 4c; CHMP4b; CHMP4c; chromatin modifying protein 4B; chromatin modifying protein 4C; Chromatin-modifying protein 4b; Chromatin-modifying protein 4c; hSnf7-2; hSnf7-3; hVps32-2; hVps32-3; SNF7 homolog associated with Alix 1; SNF7 homolog associated with Alix 3; Snf7 homologue associated with Alix 1; Snf7 homologue associated with Alix 3; SNF7-2; SNF7-3; Vacuolar protein sorting-associated protein 32-2; Vacuolar protein sorting-associated protein 32-3; vacuolar protein-sorting-associated protein 32-2; Vps32-2; Vps32-3
Gene Aliases: 2010012F05Rik; 2010012P02Rik; 2210015K02Rik; 2310010I16Rik; C20orf178; C76846; CHMP4A; CHMP4B; CHMP4C; CTPP3; CTRCT31; dJ553F4.4; RGD1309846; RGD1565889; SHAX1; SHAX3; SNF7; SNF7-2; SNF7-3; Vps32-2; VPS32B; VPS32C
Molecular Function: membrane traffic protein