Immunogen sequence: SEAFSQRVQF ADGFDEAELL AELEELEQEE LNKKMTSLEL PNVPSSSLPA
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Predicted homology: Cow: 100%; Dog: 92%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 92%; Zebrafish: 92%
CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.
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Protein Aliases: Charged multivesicular body protein 4c; CHMP4c; chromatin modifying protein 4C; Chromatin-modifying protein 4c; Snf7 homologue associated with Alix 3
Gene Aliases: 2010012P02Rik; 2210015K02Rik; 2310010I16Rik; Chmp4c; Shax3; Snf7-3
UniProt ID: (Mouse) Q9D7F7
Entrez Gene ID: (Mouse) 66371
Molecular Function: transfer/carrier protein