Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji, mouse stomach.
Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (92%), Pig (100%), Chicken (94%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein family. These proteins are components of ESCRT-III, a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies. Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: apoptosis-related protein PNAS-2; Charged multivesicular body protein 5; chromatin modifying protein 5; Chromatin-modifying protein 5; HGNC:26942; hVps60; likely ortholog of H. sapiens SNF7 domain containing 2; SNF7 domain containing 2; SNF7 domain-containing protein 2; Vacuolar protein sorting-associated protein 60; Vps60
Gene Aliases: 2210412K09Rik; AW545668; C9orf83; CGI-34; CHMP5; HSPC177; PNAS-114; PNAS-2; SNF7DC2; Vps60
Molecular Function: membrane traffic protein