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Proteintech
CHMP6 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
16278-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHMP6 Fusion Protein Ag9357 (1-201 aa encoded by BC010108)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGNLFGRKK QSRVTEQDKA ILQLKQQRDK LRQYQKRIAQ QLERERALAR QLLRDGRKER AKLLLKKKRY QEQLLDRTEN QISSLEAMVQ SIEFTQIEMK VMEGLQFGNE CLNKMHQVMS IEEVERILDE TQEAVEYQRQ IDELLAGSFT QEDEDAILEE LSAITQEQIE LPEVPSEPLP EKIPENVPVK ARPRQAELVA AS (1-201 aa encoded by BC010108)
Target Information
CHMP6 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 ).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: chromatin modifying protein 6; chromatin-modifying protein 6; FLJ11749; hVps20; novel SNF7 protein; similar to yeast Vps20p; unnamed protein product; vacuolar protein sorting-associated protein 20
Gene Aliases: 2400004G01Rik; RGD1565325; VPS20
UniProt ID: (Human) Q96FZ7, (Mouse) P0C0A3
Entrez Gene ID: (Human) 79643, (Mouse) 208092, (Rat) 287873
plasma membrane repair
membrane budding
autophagy
nucleus organization
vacuolar transport
mitotic metaphase plate congression
negative regulation of epidermal growth factor-activated receptor activity
macroautophagy
nuclear envelope reassembly
late endosome to vacuole transport via multivesicular body sorting pathway
multivesicular body assembly
viral budding via host ESCRT complex
regulation of protein catabolic process
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
viral budding from plasma membrane
vesicle fusion with vacuole
multivesicular body-lysosome fusion
midbody abscission
multivesicular body sorting pathway
membrane fission
autophagosome maturation
regulation of mitotic spindle assembly
late endosome to lysosome transport
regulation of exosomal secretion
ESCRT III complex assembly
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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