Peptide sequence: SGVPIFHEGM KYWSCCRRKT SDFNTFLAQE GCTKGKHMWT KKDAGKKVVP
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%
The cysteine and histidine-rich domain (CHORD)-containing protein (CHORDC1) is a member of a highly conserved protein family that contains the plant protein RAR1 and the mammalian protein melusin. In mammals, CHORDC1 is an ADP-dependent HSP90-interacting protein, and this interaction is dependent on the ability of HSP90 to bind nucleotides. Recent experiments indicate that CHORDC1 mRNA is diurnally regulated in mouse hypothalamus, and that this regulation alters during development, suggesting that CHORDC1 may play a role in circadian mechanisms in the mammalian brain.
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Protein Aliases: CHORD domain-containing protein 1; CHORD-containing protein 1; CHP-1; cysteine and histidine-rich domain (CHORD) containing 1; cysteine and histidine-rich domain (CHORD)-containing 1; cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1; Cysteine and histidine-rich domain-containing protein 1; morgana; Protein morgana
Gene Aliases: CHORDC1; CHP1
UniProt ID: (Human) Q9UHD1
Entrez Gene ID: (Human) 26973
Molecular Function: signaling molecule