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Invitrogen
CHP1 Polyclonal Antibody
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FIGURE: 1 / 8
CHP1 Antibody (PA5-29876) in ICC/IF
CHP1 Polyclonal Antibody detects Calcium binding protein P22 protein at cytoplasm by immunofluorescent analysis. Sample: HepG2 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Calcium binding protein P22 protein stained by CHP1 Polyclonal Antibody (Product # PA5-29876) diluted at 1:500. Blue: Hoechst 33342 staining.
Product Details
PA5-29876
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Calcium binding protein p22. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HeLa, HepG2, mouse liver, rat liver.
Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (90%), Xenopus laevis (94%), Chicken (96%), Rhesus Monkey (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calcineurin B homolog; Calcineurin B homologous protein 1; Calcineurin B-like protein; calcineurin homologous protein; calcium binding protein P22; Calcium-binding protein CHP; Calcium-binding protein p22; CHP; EF-hand Ca2+-binding protein p22; EF-hand calcium-binding domain-containing protein p22; p24; Sid 470; SLC9A1 binding protein; unnamed protein product
Gene Aliases: 1500003O03Rik; AA960066; AI046351; Cahp; CHP; CHP1; p22; p24; Sid470; Sid470p; SLC9A1BP; SPAX9; vac; Wrch2
UniProt ID: (Human) Q99653, (Rat) P61023, (Mouse) P61022
Entrez Gene ID: (Human) 11261, (Rat) 64152, (Mouse) 56398
microtubule bundle formation
negative regulation of protein phosphorylation
negative regulation of protein kinase activity
protein export from nucleus
potassium ion transport
small GTPase mediated signal transduction
negative regulation of phosphatase activity
protein transport
membrane docking
cytoplasmic microtubule organization
negative regulation of protein ubiquitination
negative regulation of protein autophosphorylation
negative regulation of NF-kappaB transcription factor activity
positive regulation of sodium:proton antiporter activity
sodium ion transmembrane transport
regulation of protein import into nucleus
negative regulation of protein import into nucleus
protein stabilization
positive regulation of protein transport
regulation of intracellular pH
positive regulation of protein glycosylation
membrane organization
membrane fusion
regulation of calcineurin-NFAT signaling cascade
negative regulation of calcineurin-NFAT signaling cascade
positive regulation of phospholipid biosynthetic process
cellular response to acidic pH
positive regulation of protein targeting to membrane
calcium ion regulated exocytosis
calcium-mediated signaling
transcytosis
protein oligomerization
regulation of neuron death
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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