Immunogen sequence: WELGYWLCYV NSTINPMCYA LCNKAFRDTF RLLLLCRWDK RRWRKIPKRP GSVHRTPSRQ C; Positive Samples: U-87MG, HepG2; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
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Protein Aliases: acetylcholine receptor, muscarinic 1; AChR M1; Cholinergic receptor, muscarin 1; cholinergic receptor, muscarinic 1; m1 muscarinic acetylcholine receptor protein; Muscarinic acetylcholine receptor M1
Gene Aliases: Chrm-1; CHRM1; HM1; M1; M1R