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Alomone Labs, LTD
CHRM3 Polyclonal Antibody
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FIGURE: 1 / 2
CHRM3 Antibody (AMR-006-GP-200UL) in IHC (F)
Expression of Cholinergic receptor muscarinic 3 in rat dorsal pons. Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Guinea Pig Anti-CHRM3 Antibody (#AMR-006-GP) (1:1000), followed by goat anti-guinea pig-biotin and Streptavidin-Cy3. A. CHRM3 immunoreactivity (red) appears in the locus coeruleus and motor mesencephalic nucleus. B. Pre-incubation of the antibody with CHRM3 Block... View More
Product Details
AMR-006-GP-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide EDKEMAPEKWYSLGK, corresponding to amino acid residues 653-667 of human L1CAM. Extracellular, N-terminus.
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
160 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: EDKEMAPEKWYSLGK
Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acetylcholine receptor; acetylcholine receptor, muscarinic 3; AChR M3; cholinergic receptor; cholinergic receptor, muscarinic 3, cardiac; cytotransmitter gated ion channel; G protein coupled receptor; m3 muscarinic receptor; Mm3 mAChR; muscarinic acetylcholine receptor 3; Muscarinic acetylcholine receptor M3
Gene Aliases: Chrm-3; CHRM3; EGBRS; HM3; M3; m3AChR; M3R; PBS
UniProt ID: (Human) P20309, (Mouse) Q9ERZ3, (Rat) P08483
Entrez Gene ID: (Human) 1131, (Mouse) 12671, (Rat) 24260
smooth muscle contraction
regulation of smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
chemical synaptic transmission
synaptic transmission, cholinergic
nervous system development
calcium-mediated signaling
positive regulation of insulin secretion
protein modification process
positive regulation of smooth muscle contraction
saliva secretion
acetylcholine receptor signaling pathway
ligand-gated ion channel signaling pathway
regulation of vascular smooth muscle contraction
digestion
sensory perception of chemical stimulus
regulation of vasoconstriction
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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