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Invitrogen
CHRNA10 Polyclonal Antibody
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Product Details
PA5-101716
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CHRNA10(Accession Q9GZZ6), corresponding to amino acid residues A394-L444.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CHRNA10.
Target Information
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acetylcholine receptor; acetylcholine receptor, nicotinic, alpha 10 (neuronal); cholinergic receptor; cholinergic receptor, nicotinic alpha 10; cholinergic receptor, nicotinic, alpha 10 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 10; NACHR alpha 10; NACHR alpha-10; Neuronal acetylcholine receptor subunit alpha-10; neuronal nicotinic acetylcholine receptor subunit; nicotinic acetylcholine receptor subunit alpha 10; Nicotinic acetylcholine receptor subunit alpha-10
Gene Aliases: CHRNA10; NACHRA10
UniProt ID: (Human) Q9GZZ6, (Rat) Q9JLB5
Entrez Gene ID: (Human) 57053, (Mouse) 504186, (Rat) 64574
signal transduction
positive regulation of cytosolic calcium ion concentration
synaptic transmission, cholinergic
regulation of cell proliferation
inner ear morphogenesis
detection of mechanical stimulus involved in sensory perception of sound
calcium ion transmembrane transport
cation transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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