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FIGURE: 1 / 3
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
CHRNA3 locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.
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Protein Aliases: acetylcholine receptor; Acetylcholine receptor alpha 3 (neuronal nicotine); alpha 3; cetylcholine receptor alpha 3 (neuronal nicotine); cholinergic receptor; cholinergic receptor nicotinic alpha polypeptide 4; cholinergic receptor, nicotinic alpha 3; cholinergic receptor, nicotinic, alpha 3 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 3; nAChR alpha 3; Neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha 3 subunit; neuronal nicotinic acetylcholine receptor, alpha3 subunit
Gene Aliases: (a)3; A730007P14Rik; Acra-3; Acra3; CHRNA3; LNCR2; NACHRA3; PAOD2
UniProt ID: (Human) P32297, (Mouse) Q8R4G9
Entrez Gene ID: (Human) 1136, (Mouse) 110834, (Rat) 25101
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