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Proteintech
CHRNA7 Polyclonal Antibody
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Product Details
21379-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHRNA7 Fusion Protein Ag15980 (130-321 aa encoded by BC037571)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TVIVLQYHH HDPDGGKMPK WTRVILLNWC AWFLRMKRPG EDKVRPACQH KQRRCSLASV EMSAVAPPPA SNGNLLYIGF RGLDGVHCVP TPDSGVVCGR MACSPTHDEH LLHGGQPPEG DPDLAKILEE VRYIANRFRC QDESEAVCSE WKFAACVVDR LCLMAFSVFT IICTIGILMS APNFVEAVSK DFA (130-321 aa encoded by BC037571)
Target Information
Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. CHRFAM7A, a fusion protein comprised of FAM7A and AChR alpha7, is encoded by the CHRFAM7A gene, which is located on a region of human chromosome 15 that is associated with several neuropsychiatric disorders, such as schizophrenia and bipolar affective disorder. CHRFAM7A, also known as D-10 or CHRNA7, is a 412 amino acid multi-pass membrane protein that belongs to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, a protein superfamily that mediates signal transmission at synapses. CHRFAM7A is expressed in the hippocampus. Alternative splicing of the CHRFAM7A gene produces two splice variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a7 nicotinic acetylcholine receptor; acetylcholine receptor; acetylcholine receptor alpha 7 neural; alpha 7 neuronal nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; alpha7 nicotinic receptor; alpha7-nAChR; bungarotoxin alpha; C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); cholinergic receptor; cholinergic receptor, nicotinic alpha 7; cholinergic receptor, nicotinic, alpha 7 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 7; CHRFAM7A; CHRNA7-DR1; D-10; nAChR alpha7; neuronal acetylcholine receptor protein, alpha-7 chain; Neuronal acetylcholine receptor subunit alpha-7; neuronal nicotinic acetycholine receptor alpha 7; nicotinic receptor alpha 7 subunit
Gene Aliases: Acra7; alpha7; BTX; CHRNA7; CHRNA7-2; nAchR; NACHRA7; NARAD
UniProt ID: (Human) P36544, (Rat) Q05941, (Mouse) P49582
Entrez Gene ID: (Human) 1139, (Rat) 25302, (Mouse) 11441
beta-amyloid binding
acetylcholine-activated cation-selective channel activity
ligand-gated ion channel activity
acetylcholine receptor activity
toxic substance binding
chloride channel regulator activity
acetylcholine-gated cation channel activity
acetylcholine binding
protein homodimerization activity
protein binding
drug binding
adenylate cyclase binding
protein kinase binding
ATPase binding
scaffold protein binding
ion channel activity
extracellular ligand-gated ion channel activity
ligand-gated ion channel
activation of MAPK activity
response to hypoxia
ion transport
calcium ion transport
cellular calcium ion homeostasis
signal transduction
synaptic transmission, cholinergic
memory
positive regulation of cell proliferation
negative regulation of tumor necrosis factor production
ion transmembrane transport
response to nicotine
positive regulation of angiogenesis
cognition
cation transmembrane transport
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
endocytosis
associative learning
regulation of norepinephrine secretion
neuronal action potential
sperm motility
response to food
regulation of synaptic transmission, dopaminergic
negative regulation of interleukin-1 beta production
negative regulation of interleukin-6 production
behavioral response to nicotine
T cell activation
B cell activation
regulation of membrane potential
dopamine biosynthetic process
ovulation cycle
response to ethanol
behavioral response to ethanol
regulation of inflammatory response
negative regulation of inflammatory response
generation of ovulation cycle rhythm
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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