Positive Control: Jurkat cell lysates, A549, SH-SY5Y, rat spinal cord tissue, mouse brain tissue.
Subcellular Location: Postsynaptic cell membrane, cell membrane.
Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.
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Protein Aliases: acetylcholine receptor; acetylcholine receptor beta 2 neural; acetylcholine receptor, nicotinic, beta 2 (neuronal); beta2 human neuronal nicotinic acetylcholine receptor; cholinergic receptor; cholinergic receptor nicotinic beta polypeptide 2; cholinergic receptor, nicotinic beta 2; cholinergic receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal); cholinergic receptor, nicotinic, beta subunit 2; N-alpha 1; Neuronal acetylcholine receptor non-alpha-1 chain; Neuronal acetylcholine receptor subunit beta-2; neuronal nicotinic acetylcholine receptor beta 2
Gene Aliases: [b]2-nAchR; Acrb-2; Acrb2; C030030P04Rik; CHRNB2; EFNL3; nAChRB2
Molecular Function: ligand-gated ion channel