Immunogen sequence: IAENEDALLR HLFQGYQKWV RPVLHSNDTI KVYFGLKISQ LVDVDEKNQL MTTNVWLKQE WTDHKLRWNP DDYGGIHSIK VPSESLWLPD IVLFENADGR FEGSLMTKVI VKSNGTVVWT PPASYKSSCT MDVTFFPFDR QNCSMKFGSW TYDGTMVDLI LINENVDRKD FFDNGEWEIL NAKGMKGNRR DGVYSYPFIT YSFVLRRL; Positive Samples: Mouse brain, Mouse eye, Mouse liver, Mouse skeletal muscle, Rat liver; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
The nicotinic acetylcholine receptors are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.
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Protein Aliases: acetylcholine receptor; acetylcholine receptor, neuronal nicotinic, beta-3 subunit; acetylcholine receptor, nicotinic, beta 3 (neuronal); cholinergic receptor; cholinergic receptor, nicotinic beta 3; cholinergic receptor, nicotinic, beta 3 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 3; Neuronal acetylcholine receptor subunit beta-3; neuronal nicotinic
Gene Aliases: 5730417K16Rik; Acrb3; CHRNB3