Sequence of this protein is as follows: GAPYRDPLRI PREHVHNASA HLTFNKFWRR YGKLSRHLMK VKLKKYTKFL FVRDPFVRLI SAFRSKFELE NEEFYRKFAV PMLRLYANHT SLPASAREAF RAGLKVSFAN FIQYLLDPHT EKLAPFNEHW RQVYRLCHPC QIDYDFVGKL ETLDEDAAQL LQLLQVDRQL RFPPSYRNRT ASSWEEDWFA KIPLAWRQQL YKLYEADFVL FGYPKPENLL RD
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C4ST-2; Carbohydrate sulfotransferase 12; Chondroitin 4-O-sulfotransferase 2; Chondroitin 4-sulfotransferase 2; Sulfotransferase Hlo
Gene Aliases: AI595374; C4S-2; C4ST-2; C4ST2; CHST12; UNQ500/PRO1017
Molecular Function: transferase