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Product Details
14298-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunohistochemistry (IHC) |
Assay-dependent | View 1 publication 1 publication |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
CHST15 Fusion Protein Ag5679 (103-451 aa encoded by BC050540) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.23 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: QELLISSPF HYGGFPSNPS LMDSENPSDT KEHHHQSSVN NISYMKDYPS IKLIINSITT RIEFTTRQLP DLEDLKKQEL HMFSVIPNKF LPNSKSPCWY EEFSGQNTTD PYLTNSYVLY SKRFRSTFDA LRKAFWGHLA HAHGKHFRLR CLPHFYIIGQ PKCGTTDLYD RLRLHPEVKF SAIKEPHWWT RKRFGIVRLR DGLRDRYPVE DYLDLFDLAA HQIHQGLQAS SAKEQSKMNT IIIGEASAST MWDNNAWTFF YDNSTDGEPP FLTQDFIHAF QPNARLIVML RDPVERLYSD YLYFASSNKS ADDFHEKVTE ALQLFENCML DYSLRACVYN NTLNNAMPVC (103-451 aa encoded by BC050540)
Target Information
GALNAC4S-6ST is a sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4, 6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. GALNAC4S-6ST may also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B cell RAG associated protein; B cell RAG associated protein (GALNAC4S-6ST); B-cell RAG-associated gene protein; Carbohydrate sulfotransferase 15; DKFZp781H1369; GalNAc 4-sulfate 6-O-sulfotransferase; GalNAc4S-6ST; hBRAG; MGC34346; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase; RP11-47G11.1
Gene Aliases: 4631426J05Rik; BRAG; CHST15; GALNAC4S-6ST; GALNAC4S6ST; GalNAcS-6ST; KIAA0598; MAd5; mKIAA0598
UniProt ID: (Human) Q7LFX5, (Rat) Q8CHI9, (Mouse) Q91XQ5
Entrez Gene ID: (Human) 51363, (Rat) 286974, (Mouse) 77590
Molecular Function:
transferase
Performance Guarantee
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