In direct ELISAs and Western blots, approximately 40% cross-reactivity with recombinant human (rh) CHST4 is observed and less than 5% cross-reactivity with recombinant mouse CHST5 and rhCHST6 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.
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Protein Aliases: Carbohydrate sulfotransferase 4; galactose/N-acetylglucosamine/N-acetylgalactosamine 6-O-sulfotransferase 3; galactose/N-acetylglucosamine/N-acetylglucosamine; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3; GlcNAc6ST-2; GlcNAc6ST2; GST-3; GST3; HEC-GlcNAc6ST; HECGLCNAC6ST; high endothelial cell GlcNAC-6-sulphotransferase; High endothelial cells N-acetylglucosamine 6-O-sulfotransferase; L-selectin ligand sulfotransferase; LSST; N-acetylglucosamine 6-O-sulfotransferase 2
Gene Aliases: Chst4; Gn6st-2; GST-3; Gst3; HEC-GlcNAc6ST
UniProt ID: (Mouse) Q9R1I1
Entrez Gene ID: (Mouse) 26887