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CIDE-A Polyclonal Antibody
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FIGURE: 1 / 3
CIDE-A Antibody (600-401-AK4) in ICC/IF
Immunofluorescence Microscopy of CIDE-A antibody. Tissue: Mouse heart cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: CIDE-A antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: CIDE-A is nuclear and is also localized in lipid droplets. Staining: CIDE-A as red fluorescent signal.
Product Details
600-401-AK4
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-CIDE-A antibody was prepared from whole rabbit serum produced by repeated immunizations with a 18 amino acid peptide near the C-terminus of human CIDE-A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell death activator CIDE-A; Cell death-inducing DFFA-like effector A; cide a; Lipid transferase CIDEA
Gene Aliases: AW212747; Cidea
UniProt ID: (Mouse) O70302
Entrez Gene ID: (Mouse) 12683
temperature homeostasis
transcription, DNA-templated
regulation of transcription, DNA-templated
lipid metabolic process
apoptotic process
cell death
positive regulation of sequestering of triglyceride
lipid storage
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of tumor necrosis factor production
negative regulation of cytokine secretion
negative regulation of lipid catabolic process
negative regulation of execution phase of apoptosis
regulation of apoptotic DNA fragmentation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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