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Proteintech
CIDEA Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
13170-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CIDEA Fusion Protein Ag3824 (1-253 aa encoded by BC031896)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The MW of this protein is 25 kDa, and this antibody specifically recognizes the 25 kDa protein.
Immunogen sequence: MRGDRASGG PGNHNGSWAR EGPRLGPSWK RGLWSPRGGP NRPAEPSRPL TFMGSQTKRV LFTPLMHPAR PFRVSNHDRS SRRGVMASSL QELISKTLDA LVIATGLVTL VLEEDGTVVD TEEFFQTLGD NTHFMILEKG QKWMPGSQHV PTCSPPKRSG IARVTFDLYR LNPKDFIGCL NVKATMYEMY SVSYDIRCTG LKGLLRSLLR FLSYSAQVTG QFLIYLGTYM LRVLDDKEER PSLRSQAKGR FTCG (1-253 aa encoded by BC031896)
Target Information
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cell death activator CIDE-A; cell death-inducing DFFA-like effector A; cell death-inducing DNA fragmentation factor, alpha subunit-like effector A; cide a; unnamed protein product
Gene Aliases: CIDE-A
UniProt ID: (Human) O60543, (Mouse) O70302
Entrez Gene ID: (Human) 1149, (Mouse) 12683, (Rat) 291541
temperature homeostasis
negative regulation of cytokine production
lipid metabolic process
apoptotic process
lipid storage
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of tumor necrosis factor production
response to stilbenoid
fat cell differentiation
negative regulation of lipid catabolic process
negative regulation of multicellular organismal process
cellular response to cold
intermembrane lipid transfer
negative regulation of cold-induced thermogenesis
lipid droplet fusion
negative regulation of execution phase of apoptosis
regulation of apoptotic DNA fragmentation
biological_process
positive regulation of transcription, DNA-templated
positive regulation of cold-induced thermogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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