PA5-29654 targets CIDE A in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-29654 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 190 of Human CIDE A.
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This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Two alternative transcripts encoding different isoforms have been identified.
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Protein Aliases: Cell death activator CIDE-A; Cell death-inducing DFFA-like effector A; CIDE-A
Gene Aliases: CIDE-A; CIDEA
UniProt ID: (Human) O60543
Entrez Gene ID: (Human) 1149