Immunogen sequence: MVEAIVEFD YQAQHDDELT ISVGEIITNI RKEDGGWWEG QINGRRGLFP DNFVREIKKE MKKDPLTNKA PEKPLHEVPS GNSLLSSETI LRTNKRGERR RRRCQVAFSY LPQNDDELEL KVGDIIEVVG EVEEGWWEGV LNGKTGMFPS NFIKELSGES DELGISQDEQ LSKSSLRETT GSESDGGDSS STKSEGANGT VATAAIQPKK VKGVGFGDIF KDKPIKLRPR SIEVENDFLP VEKTIGKKLP ATTATPDSSK TEMDSRTKSK DYCKVIFPYE AQNDDELTIK EGDIVTLINK DCIDVGWWEG ELNGRRGVFP DNFVKLLPP (1-328 aa encoded by BC015806 )
This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.
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Protein Aliases: c-Cbl-interacting protein; Cbl-interacting protein of 85 kDa; CD2-binding protein 3; CD2BP3; HSB-1; Human Src family kinase-binding protein 1; migration-inducing gene 18; SH3 domain-containing kinase-binding protein 1; SH3-domain kinase binding protein 1; Src family kinase-binding protein 1; src-related kinase binding protein-1
Gene Aliases: CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18; SH3KBP1
UniProt ID: (Human) Q96B97
Entrez Gene ID: (Human) 30011