Bioss

CIRBP Polyclonal Antibody

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CIRBP Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti-CIRBP Polyclonal Antibody, Unconjugated (bs-7790R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Product Details

BS-7790R

Applications	Tested Dilution	Publications
Western Blot (WB)	1:300	-
Immunohistochemistry (Paraffin) (IHC (P))	1:200	-
Immunohistochemistry (Frozen) (IHC (F))	1:100-1:500	-
Immunocytochemistry (ICC/IF)	1:50-1:200	-
ELISA (ELISA)	1:500-1:1,000	-

Product Specifications
Species Reactivity	Mouse, Rat, Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	KLH conjugated synthetic peptide derived from human CIRBP, amino acids 61-172. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein A
Storage buffer	PBS with 50% glycerol, 1% BSA
Contains	0.09% sodium azide
Storage conditions	-20°C

Target Information

CIRBP is cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator and seems to play an essential role in cold-induced suppression of cell proliferation. It binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. This protein acts as a translational repressor and promotes assembly of stress granules (SGs), when overexpressed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A18 hnRNP; cold inducible RNA-binding protein; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; Glycine-rich RNA-binding protein CIRP; testicular tissue protein Li 39

Gene Aliases: A18HNRNP; CIRBP; CIRP; R74941

UniProt ID: (Human) Q14011, (Rat) P60825, (Mouse) P60824

Entrez Gene ID: (Human) 1153, (Rat) 81825, (Mouse) 12696

Function(s)

response to cold response to UV negative regulation of translation stress granule assembly positive regulation of translation mRNA stabilization

Process(es)

nucleotide binding mRNA 3'-UTR binding protein binding translation repressor activity poly(A) RNA binding small ribosomal subunit rRNA binding nucleic acid binding RNA binding