Recommended positive controls: HCT116.
Predicted reactivity: Mouse (94%), Rat (94%), Chicken (94%), Rhesus Monkey (100%), Chimpanzee (96%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
CIRBP is cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator and seems to play an essential role in cold-induced suppression of cell proliferation. It binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. This protein acts as a translational repressor and promotes assembly of stress granules (SGs), when overexpressed.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A18 hnRNP; cold inducible RNA-binding protein; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; Glycine-rich RNA-binding protein CIRP; testicular tissue protein Li 39
Gene Aliases: A18HNRNP; CIRBP; CIRP
UniProt ID: (Human) Q14011
Entrez Gene ID: (Human) 1153