This target displays homology in the following species: Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
CIS contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: CIS; CIS-1; cytokine-inducible SH2 protein; Cytokine-inducible SH2-containing protein; SOCS; Suppressor of cytokine signaling
Gene Aliases: AI385595; Cis; CIS1; Cish; F17; F23
UniProt ID: (Mouse) Q62225
Entrez Gene ID: (Mouse) 12700