The synthetic peptide sequence is 241-258aa, LPLPRRMADYLRQYPFQL
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
CIS contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CIS; CIS-1; cytokine inducible SH2-containing protein; cytokine inducible SH2-containing protein 1; cytokine-inducible inhibitor of signaling type 1B; cytokine-inducible SH2 protein; Cytokine-inducible SH2-containing protein; Protein G18; SOCS; Suppressor of cytokine signaling
Gene Aliases: AI385595; BACTS2; CIS; CIS-1; CIS1; CISH; F17; F23; G18; SOCS