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Invitrogen
CITED2 Polyclonal Antibody
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Product Details
PA5-103000
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CITED2(Accession Q99967), corresponding to amino acid residues Y134-G184.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CITED2.
Target Information
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of HIF1a to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Three transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cbp/p300-interacting transactivator 2; Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; melanocyte specific gene 2; melanocyte-specific gene 1-related gene 1; MRG-1; MSG-related protein 1; MSG1-related gene 1; P35srj
Gene Aliases: AI835299; ASD8; CITED2; ER154-like; MRG-1; MRG1; Msg2; P35SRJ; VSD2
UniProt ID: (Human) Q99967, (Mouse) O35740
Entrez Gene ID: (Human) 10370, (Rat) 114490, (Mouse) 17684
RNA polymerase II transcription coactivator activity
RNA polymerase II transcription corepressor activity
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
histone acetyltransferase binding
LBD domain binding
RNA polymerase II activating transcription factor binding
molecular_function
SMAD binding
transcription cofactor activity
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
liver development
outflow tract morphogenesis
regulation of organ formation
transcription, DNA-templated
determination of left/right symmetry
heart development
sex determination
cell proliferation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell-cell adhesion
cell differentiation
negative regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
response to fluid shear stress
positive regulation of peroxisome proliferator activated receptor signaling pathway
adrenal cortex formation
negative regulation of apoptotic process
response to estrogen
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
ventricular septum morphogenesis
embryonic heart tube left/right pattern formation
left/right pattern formation
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
left/right axis specification
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
positive regulation of male gonad development
blood vessel development
vasculogenesis
branching involved in ureteric bud morphogenesis
in utero embryonic development
kidney development
trophectodermal cell differentiation
neural tube formation
neural tube closure
embryonic placenta development
vasculature development
heart looping
morphogenesis of an epithelium
lens morphogenesis in camera-type eye
hematopoietic progenitor cell differentiation
leukocyte differentiation
endocardial cushion development
ventricular septum development
regulation of transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
central nervous system development
peripheral nervous system development
cell aging
male gonad development
response to mechanical stimulus
cranial nerve morphogenesis
adrenal gland development
granulocyte differentiation
skeletal muscle cell differentiation
decidualization
thymus development
embryonic camera-type eye morphogenesis
erythrocyte development
embryonic process involved in female pregnancy
bone morphogenesis
cardiac septum morphogenesis
pulmonary artery morphogenesis
cardiac neural crest cell development involved in heart development
determination of heart left/right asymmetry
cellular response to growth factor stimulus
regulation of nucleic acid-templated transcription
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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