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Invitrogen
CITED2 Polyclonal Antibody
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Product Details
PA5-103000
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CITED2(Accession Q99967), corresponding to amino acid residues Y134-G184.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CITED2.
Target Information
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of HIF1a to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Three transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cbp/p300-interacting transactivator 2; melanocyte specific gene 2; melanocyte-specific gene 1-related gene 1; MRG-1; MSG-related protein 1; MSG1-related gene 1; P35srj
Gene Aliases: AI835299; ASD8; CITED2; ER154-like; MRG-1; MRG1; Msg2; P35SRJ; VSD2
UniProt ID: (Human) Q99967, (Mouse) O35740
Entrez Gene ID: (Human) 10370, (Rat) 114490, (Mouse) 17684
chromatin binding
transcription coactivator activity
transcription corepressor activity
protein binding
protein domain specific binding
histone acetyltransferase binding
SMAD binding
LBD domain binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
molecular function activator activity
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
RNA polymerase II transcription corepressor activity
molecular_function
transcription factor activity, sequence-specific DNA binding
transcription cofactor activity
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
blood vessel development
vasculogenesis
response to hypoxia
in utero embryonic development
trophectodermal cell differentiation
neural tube formation
neural tube closure
liver development
embryonic placenta development
vasculature development
heart looping
lens morphogenesis in camera-type eye
hematopoietic progenitor cell differentiation
leukocyte differentiation
determination of left/right asymmetry in lateral mesoderm
outflow tract morphogenesis
regulation of organ formation
endocardial cushion development
ventricular septum development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
determination of left/right symmetry
central nervous system development
peripheral nervous system development
heart development
sex determination
cell proliferation
male gonad development
response to mechanical stimulus
positive regulation of gene expression
negative regulation of gene expression
cranial nerve morphogenesis
positive regulation of cell-cell adhesion
cell differentiation
adrenal gland development
negative regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
granulocyte differentiation
response to fluid shear stress
positive regulation of peroxisome proliferator activated receptor signaling pathway
adrenal cortex formation
skeletal muscle cell differentiation
nodal signaling pathway
negative regulation of apoptotic process
response to estrogen
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
decidualization
spleen development
thymus development
embryonic camera-type eye morphogenesis
erythrocyte development
uterus development
embryonic process involved in female pregnancy
bone morphogenesis
cardiac septum morphogenesis
ventricular septum morphogenesis
embryonic heart tube left/right pattern formation
left/right pattern formation
pulmonary artery morphogenesis
cardiac neural crest cell development involved in heart development
determination of heart left/right asymmetry
left/right axis specification
cellular response to growth factor stimulus
cellular response to hypoxia
cellular senescence
positive regulation of male gonad development
branching involved in ureteric bud morphogenesis
kidney development
morphogenesis of an epithelium
cell aging
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
regulation of nucleic acid-templated transcription
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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