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CITED2 Antibody (PA5-85562) in ICC/IF
CITED2 Polyclonal Antibody detects CITED2 protein at nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CITED2 protein stained by CITED2 Polyclonal Antibody (Product # PA5-85562) diluted at 1:1,000. Blue: Hoechst 33342 staining.
Product Details
PA5-85562
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human CITED2.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2792702
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (99%), Rat (100%), Sheep (98%), Bovine (98%).
Positive Control: 293T, HeLa, HepG2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of HIF1a to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Three transcript variants encoding the same protein have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cbp/p300-interacting transactivator 2; Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; melanocyte-specific gene 1-related gene 1; MRG-1; MSG-related protein 1; MSG1-related gene 1; P35srj
Gene Aliases: ASD8; CITED2; MRG-1; MRG1; P35SRJ; VSD2
UniProt ID: (Human) Q99967
Entrez Gene ID: (Human) 10370
RNA polymerase II transcription coactivator activity
RNA polymerase II transcription corepressor activity
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
histone acetyltransferase binding
LBD domain binding
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
liver development
outflow tract morphogenesis
regulation of organ formation
transcription, DNA-templated
determination of left/right symmetry
heart development
sex determination
cell proliferation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell-cell adhesion
cell differentiation
negative regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
response to fluid shear stress
positive regulation of peroxisome proliferator activated receptor signaling pathway
adrenal cortex formation
negative regulation of apoptotic process
response to estrogen
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
ventricular septum morphogenesis
embryonic heart tube left/right pattern formation
left/right pattern formation
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
left/right axis specification
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
positive regulation of male gonad development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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