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Invitrogen
CK1 epsilon Polyclonal Antibody
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Product Details
PA5-95934
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 247-416 of human CSNK1E (NP_6894071)
Conjugate
Form
Liquid
Concentration
0.93 mg/mL
Amount
93 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EFSTYLNFCR SLRFDDKPDY SYLRQLFRNL FHRQGFSYDY VFDWNMLKFG AARNPEDVDR ERREHEREER MGQLRGSATR ALPPGPPTGA TANRLRSAAE PVASTPASRI QPAGNTSPRA ISRVDRERKV SMRLHRGAPA NVSSSDLTGR QEVSRIPASQ TSVPFDHLGK; Positive Samples: HeLa, 293T; Cellular Location: Cytoplasm, Nucleus
Target Information
CSNK1E (CK1 epsilon) is a serine/threonine kinase implicated in a wide range of cellular functions, including vesicular trafficking, DNA damage repair, cell cycle progression, and cytokinesis. CSNK1E phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: casein kinase 1; Casein kinase I isoform epsilon; CK1e; CKI, epsilon; CKI-epsilon; CSNK1E; KC1 epsilon; MGC10398; OTTHUMP00000063258; OTTHUMP00000063263; RP1-5O6.1
Gene Aliases: AI426939; AI551861; AW457082; CK1epsilon; CKIe; CKIepsilon; CSNK1E; HCKIE; KC1epsilon; tau
UniProt ID: (Human) P49674, (Mouse) Q9JMK2
Entrez Gene ID: (Human) 1454, (Mouse) 27373, (Rat) 58822
nucleotide binding
RNA binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
poly(A) RNA binding
non-receptor serine/threonine protein kinase
DNA repair
protein phosphorylation
endocytosis
signal transduction
protein localization
regulation of Wnt signaling pathway
positive regulation of Wnt signaling pathway
negative regulation of Wnt signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of protein localization
circadian regulation of gene expression
non-canonical Wnt signaling pathway
regulation of circadian rhythm
rhythmic process
circadian behavior
negative regulation of small GTPase mediated signal transduction
canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of beta-amyloid formation
cellular response to nerve growth factor stimulus
positive regulation of non-canonical Wnt signaling pathway
circadian rhythm
regulation of cell shape
Wnt signaling pathway
phosphorylation
peptidyl-serine phosphorylation
cellular protein localization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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