This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: SRLQHVEDGV LSMQVASARQ TESLESLLSK SQEHEQRLAA LQGRLEGLGS SEADQDGLAS TVRSLGETQL VLYGDVEELK RSVGELPSTV ESLQKVQEQV HTLLSQDQAQ
Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 68%.
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14. 7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 63 kDa membrane protein; 63-kDa cytoskeleton-linking membrane protein; Climp-63; Cytoskeleton-associated protein 4; transmembrane protein (63kD), endoplasmic reticulum/Golgi intermediate compartment; type-II transmembrane protein p63
Gene Aliases: CKAP4; CLIMP-63; ERGIC-63; p63
UniProt ID: (Human) Q07065
Entrez Gene ID: (Human) 10970