Recommended positive controls: 293T, A431, HeLa, HepG2.
Predicted reactivity: Mouse (91%), Rat (91%), Dog (94%), Pig (94%), Rabbit (92%), Chicken (84%), Bovine (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Basic-type mitochondrial creatine kinase; Creatine kinase S-type, mitochondrial; creatine kinase, mitochondrial 2 (sarcomeric); EC 18.104.22.168; Mib-CK; S-MtCK; Sarcomeric mitochondrial creatine kinase
Gene Aliases: CKMT2; SMTCK
UniProt ID: (Human) P17540
Entrez Gene ID: (Human) 1160