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Proteintech
CXCR3B Monoclonal Antibody (1B2D6), CoraLite® Plus 488
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Product Details
CL488-60065
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1B2D6
Immunogen
Peptide
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Historically, CD183 was the third CXC chemokine receptor discovered and therefore, commonly designated as CXCR3. Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. The CXC chemokine receptor (CXCR) 3, a G-protein-coupled 7-transmembrane receptor, is expressed at high levels on activated and memory T cells, B cells, natural killer cells, and plasmacytoid monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-X-C chemokine receptor type 3; CD183; chemokine (C-X-C motif) receptor 3; chemokine (C-X-C motif) receptor 3 isoform CXCR3_1; chemokine (C-X-C motif) receptor 3 isoform CXCR3_2; chemokine receptor 3; CKR-L2; CXC-R3; CXCR3-B; G protein-coupled receptor; G protein-coupled receptor; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; Mig receptor; unnamed protein product
Gene Aliases: CD182; CD183; CKR-L2; CMKAR3; CXCR3; GPR9; IP10-R; Mig-R; MigR
UniProt ID: (Human) P49682
Entrez Gene ID: (Human) 2833
angiogenesis
negative regulation of endothelial cell proliferation
regulation of leukocyte migration
apoptotic process
chemotaxis
inflammatory response
immune response
cell adhesion
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
T cell chemotaxis
negative regulation of angiogenesis
calcium-mediated signaling
regulation of cell adhesion
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of chemotaxis
positive regulation of release of sequestered calcium ion into cytosol
cell chemotaxis
chemokine-mediated signaling pathway
negative regulation of execution phase of apoptosis
positive regulation of execution phase of apoptosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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