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Proteintech
RBM4 Monoclonal Antibody (3H3F12), CoraLite® Plus 488
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Product Details
CL488-60292
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
3H3F12
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED AIRNLHHYKL HGVNINVEAS KNKSKTSTKL HVGNISPTCT NKELRAKFEE YGPVIECDIV KDYAFVHMER AEDAVEAIRG LDNTEFQGEP PSLGRGLNTR LCAENGWISK RRGLVKITAV GWLVMKK
Target Information
RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hLark; Lark homolog; rna-binding; RNA-binding motif protein 4; RNA-binding motif protein 4a; RNA-binding protein 4; transcriptional coactivator CoAZ; unnamed protein product; zinc finger CCHC-type and RNA binding motif 3A
Gene Aliases: LARK; RBM4; RBM4A; ZCCHC21; ZCRB3A
UniProt ID: (Human) Q9BWF3
Entrez Gene ID: (Human) 5936
regulation of alternative mRNA splicing, via spliceosome
cap-independent translational initiation
IRES-dependent translational initiation
RNA processing
mRNA processing
circadian rhythm
RNA splicing
regulation of gene expression
negative regulation of translation
cell differentiation
pancreas development
gene silencing by RNA
negative regulation of translation in response to stress
circadian regulation of gene expression
miRNA mediated inhibition of translation
insulin secretion involved in cellular response to glucose stimulus
enteroendocrine cell differentiation
glucose homeostasis
entrainment of circadian clock by photoperiod
positive regulation of translation
negative regulation of translational initiation
regulation of insulin receptor signaling pathway
response to arsenic-containing substance
regulation of nucleocytoplasmic transport
positive regulation of muscle cell differentiation
circadian regulation of translation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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