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Proteintech
DDB1 Monoclonal Antibody (4F6C6), CoraLite® Plus 488
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Product Details
CL488-66010
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
4F6C6
Immunogen
DDB1 fusion protein Ag17903
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MSYNYVVTA QKPTAVNGCV TGHFTSAEDL NLLIAKNTRL EIYVVTAEGL RPVKEVGMYG KIAVMELFRP KGESKDLLFI LTAKYNACIL EYKQSGESID IITRAHGNVQ DRIGRPSETG IIGIIDPECR MIGLRLYDGL FKVIPLDRDN KELKAFNIRL EELHVIDVKF LYGCQAPTIC FVYQDPQGRH VKTYEVSLRE KEFNKGPWKQ ENVEAEASMV IAVPEPFGGA IIIGQESITY HNGDKYLAIA PPIIKQSTIV CHNRVDPNGS RYLLGDMEGR LFMLLLEKEE QMDGTVTLKD LRVELLGETS IAECLTYLDN GVVFVGSRLG DSQLVKLNVD SNEQGSYVVA METFTNLGPI VDMCVVDLER QGQGQLVTCS GAFKEGSLRI IRNGIGIHEH A
Target Information
The DNA damage-binding protein from HeLa cells is associated with polypeptides of relative mass 124,000 (DDB1) and 41,000 (DDB2) as determined by SDS-polyacrylamide gels. To test whether the DNA-repair defect in the subset of XPE patients that lack DNA damage-binding activity is caused by a defect in DDB, Keeney et al. (1994) injected purified human DDB protein into XPE cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: damage specific DNA binding protein 1; damage-specific DNA binding protein 1, 127kDa; Damage-specific DNA-binding protein 1; damage-specific DNA-binding protein, DNA repair; damaged-DNA recognition protein 1; DDB p127 subunit; DDBa; DNA damage-binding protein 1; DNA damage-binding protein a; DNA repair protein; HBV X-associated protein 1; unnamed protein product; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; UV-DDB 1; XAP-1; xeroderma pigmento; Xeroderma pigmentosum group E-complementing protein; XPCe; XPE-BF; XPE-binding factor
Gene Aliases: 127kDa; AA408517; DDB1; DDBA; p127-Ddb1; UV-DDB1; WHIKERS; XAP1; XPCE; XPE; XPE-BF
UniProt ID: (Human) Q16531, (Mouse) Q3U1J4
Entrez Gene ID: (Human) 1642, (Mouse) 13194, (Rat) 64470
DNA repair
nucleotide-excision repair
ubiquitin-dependent protein catabolic process
apoptotic process
cellular response to DNA damage stimulus
spindle assembly involved in female meiosis
proteasomal protein catabolic process
Wnt signaling pathway
protein ubiquitination
viral release from host cell
cellular response to UV
ectopic germ cell programmed cell death
regulation of circadian rhythm
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
epigenetic programming in the zygotic pronuclei
positive regulation of viral genome replication
positive regulation of gluconeogenesis
positive regulation of protein catabolic process
positive regulation by virus of viral protein levels in host cell
rhythmic process
negative regulation of developmental process
interaction with symbiont
negative regulation of protein kinase B signaling
type I interferon signaling pathway
UV-damage excision repair
base-excision repair, AP site formation via deaminated base removal
regulation of mitotic cell cycle phase transition
negative regulation of reproductive process
histone H2A monoubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of viral release from host cell
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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