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GM2A Monoclonal Antibody (1E4D3), CoraLite® Plus 488
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FIGURE: 1 / 1
GM2A Antibody (CL488-66080) in Flow
1x10^6 HeLa cells were intracellularly stained with 0.4 µg Coralite Plus 488 Gm2a Monoclonal Antibody (CL488-66080, Clone: 1E4D3) (red), or 0.4 µg Isotype Control (CL488-66360-2) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF,00011-C).
Product Details
CL488-66080
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1E4D3
Immunogen
GM2A fusion protein Ag4394
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: MQSLMQAPLL IALGLLLAAP AQAHLKKPSQ LSSFSWDNCD EGKDPAVIRS LTLEPDPIVV PGNVTLSVVG STSVPLSSPL KVDLVLEKEV AGLWIKIPCT DYIGSCTFEH FCDVLDMLIP TGEPCPEPLR TYGLPCHCPF KEGTYSLPKS EFVVPDLELP SWLTTGNYRI ESVLSSSGKR LGCIKIAASL KGI
Target Information
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cerebroside sulfate activator protein; Ganglioside GM2 activator; GM2 ganglioside activator; GM2-activator protein; GM2-AP; SAP-3; shingolipid activator protein 3; Sphingolipid activator protein 3; unnamed protein product
Gene Aliases: GM2-AP; GM2A; GM2AP; SAP-3
UniProt ID: (Human) P17900
Entrez Gene ID: (Human) 2760
ganglioside metabolic process
lipid metabolic process
sphingolipid metabolic process
ganglioside catabolic process
lipid transport
learning or memory
oligosaccharide catabolic process
lipid storage
glycosphingolipid catabolic process
neurological system process
neuromuscular process controlling balance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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