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Proteintech

RAC1 Monoclonal Antibody (4A4B11), CoraLite® Plus 488

1 Reference
View all (10) RAC1 antibodies

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Additional Information:

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Product Details

CL488-66122

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

4A4B11

Immunogen

Full length RAC1 protein.

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

2 mg/mL

Amount

200 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Target Information

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: cell migration-inducing gene 5 protein; MGC111543; p21-Rac1; Rac1ins; ras-like protein; ras-like protein TC25; RAS-related C3 botulinum substrate 1; ras-related C3 botulinum toxin substrate; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); rho family, small GTP binding protein Rac1; small GTP binding protein; Rac1; Rho-related protein; unnamed protein product

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Gene Aliases: D5Ertd559e; MIG5; MRD48; p21-Rac1; Rac-1; TC-25

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UniProt ID: (Human) P63000, (Mouse) P63001, (Rat) Q6RUV5

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Entrez Gene ID: (Human) 5879, (Mouse) 19353, (Rat) 363875

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Function(s)
GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding enzyme binding protein kinase binding GTP-dependent protein binding thioesterase binding macromolecular complex binding Rho GDP-dissociation inhibitor binding small GTPase binding histone deacetylase binding ATPase binding
Process(es)
neuron migration positive regulation of protein phosphorylation auditory receptor cell morphogenesis mast cell chemotaxis sphingosine-1-phosphate signaling pathway epithelial cell morphogenesis endocytosis phagocytosis, engulfment chemotaxis hyperosmotic response cytoskeleton organization actin filament organization cell adhesion cell-matrix adhesion establishment or maintenance of cell polarity enzyme linked receptor protein signaling pathway G-protein coupled receptor signaling pathway small GTPase mediated signal transduction axon guidance motor neuron axon guidance regulation of cell shape regulation of lamellipodium assembly positive regulation of lamellipodium assembly positive regulation of endothelial cell migration regulation of fibroblast migration negative regulation of fibroblast migration positive regulation of cell-substrate adhesion regulation of neuron maturation dendrite development cell migration Rac protein signal transduction cerebral cortex radially oriented cell migration embryonic olfactory bulb interneuron precursor migration cerebral cortex GABAergic interneuron development regulation of cell morphogenesis cell projection assembly lamellipodium assembly actin cytoskeleton organization actin filament polymerization regulation of cell migration positive regulation of actin filament polymerization cortical cytoskeleton organization forebrain development positive regulation of microtubule polymerization response to lipopolysaccharide negative regulation of interleukin-23 production regulation of actin cytoskeleton organization substrate adhesion-dependent cell spreading non-canonical Wnt signaling pathway positive regulation of insulin secretion involved in cellular response to glucose stimulus angiotensin-activated signaling pathway superoxide anion generation erythrocyte enucleation engulfment of apoptotic cell cell-cell junction organization regulation of nitric oxide biosynthetic process bone resorption positive regulation of DNA replication regulation of JAK-STAT cascade hepatocyte growth factor receptor signaling pathway regulation of neuronal synaptic plasticity anatomical structure arrangement neuron projection morphogenesis dendrite morphogenesis cell motility homeostasis of number of cells homeostasis of number of cells within a tissue positive regulation of filopodium assembly regulation of stress fiber assembly positive regulation of stress fiber assembly localization within membrane positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling synaptic transmission, GABAergic Wnt signaling pathway, planar cell polarity pathway regulation of respiratory burst cell chemotaxis positive regulation of dendritic spine development regulation of cell adhesion involved in heart morphogenesis regulation of ERK5 cascade cellular response to mechanical stimulus semaphorin-plexin signaling pathway dopaminergic neuron differentiation protein localization to plasma membrane positive regulation of neutrophil chemotaxis cochlea morphogenesis ruffle assembly postsynaptic actin cytoskeleton organization regulation of postsynapse assembly positive regulation of substrate adhesion-dependent cell spreading positive regulation of ruffle assembly regulation of synaptic vesicle endocytosis regulation of neutrophil migration positive regulation of bicellular tight junction assembly midbrain dopaminergic neuron differentiation positive regulation of ovarian follicle development inflammatory response response to wounding anatomical structure morphogenesis regulation of hydrogen peroxide metabolic process regulation of cell-substrate adhesion ruffle organization positive regulation of Rho protein signal transduction intracellular signal transduction respiratory burst negative regulation of receptor-mediated endocytosis multicellular organismal homeostasis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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