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Proteintech
SMARCE1 Monoclonal Antibody (1F3D6), CoraLite® Plus 488
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Product Details
CL488-66182
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F3D6
Immunogen
SMARCE1 fusion protein Ag1161
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
2 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: DLKLWEIGK IIGGMWRDLT DEEKQEYLNE YEAEKIEYNE SMKAYHNSPA YLAYINAKSR AEAALEEESR QRQSRMEKGE PYMSIQPAED PDDYDDGFSM KHTATARFQR NHRLISEILS ESVVPDVRSV VTTARMQVLK RQVQSLMVHQ RKLEAELLQI EERHQEKKRK FLESTDSFNN ELKRLCGLKV EVDMEKIAAE IAQAEEQARK RQEEREKEAA EQAERSQSSI VPEEEQAANK GEEKKDDENI PMETEETHLE ETTESQQNGE EGTSTPEDKE SGQEGVDSMA EEGTSDSNTG SESNSATVEE PPTDPIPEDE KKE
Target Information
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAF57; BRG1-associated factor 57; chromatin remodeling complex BRG1-associated factor 57; SMARCE 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; unnamed protein product
Gene Aliases: BAF57; CSS5; SMARCE1
UniProt ID: (Human) Q969G3
Entrez Gene ID: (Human) 6605
chromatin organization
nucleosome disassembly
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
nervous system development
neurogenesis
regulation of mitotic metaphase/anaphase transition
positive regulation of T cell differentiation
positive regulation of cell differentiation
positive regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
regulation of G0 to G1 transition
positive regulation of stem cell population maintenance
regulation of G1/S transition of mitotic cell cycle
positive regulation of double-strand break repair
regulation of nucleotide-excision repair
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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