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Adiponectin Monoclonal Antibody (5D8A7), CoraLite® 488

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Adiponectin Monoclonal Antibody (5D8A7), CoraLite® 488

Product Details

CL488-66239

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

5D8A7

Immunogen

Recombinant protein
View immunogen

Conjugate

CoraLite® 488 CoraLite® 488 CoraLite® 488

Excitation/Emission Max

490/515 nm

Form

Liquid

Purification

Protein G

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MLLLGAVLLL LALPGHDQET TTQGPGVLLP LPKGACTGWM AGIPGHPGHN GAPGRDGRDG TPGEKGEKGD PGLIGPKGDI GETGVPGAEG PRGFPGIQGR KGEPGEGAYV YRSAFSVGLE TYVTIPNMPI RFTKIFYNQQ NHYDGSTGKF HCNIPGLYYF AYHITVYMKD VKVSLFKKDK AMLFTYDQYQ ENNVDQASGS VLLHLEVGDQ VWLQVYGEGE RNGLYADNDN DSTFTGFLLY HDTN

Target Information

Adiponectin is a protein hormone secreted exclusively by adipocytes that regulates the metabolism of lipids and glucose. Adiponectin has been shown to play a role in various physiological processes including homeostasis and obesity. Decreased levels of adiponectin are associated with obese individuals as well as insulin resistance and hyperinsulinemia (type 2 diabetes). In mice adiponectin has been shown to improve insulin signaling, thus ameliorating insulin resistance. Through activation of AMP kinase and PPAR-alpha, adiponectin can increase fatty acid transport, oxidation, and dissipation in skeletal muscle, leading to a reduction of intramyocellular lipid levels and thus improved insulin signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 30 kDa adipocyte complement-related protein; ACRP30; adipocyte complement related protein; Adipocyte complement-related 30 kDa protein; adipocyte, C1Q and collagen domain containing; Adipocyte, C1q and collagen domain-containing protein; Adipocyte-specific protein AdipoQ; Adiponectin; Adipose most abundant gene transcript 1 protein; adipose specific collagen-like factor; ADPIOQ; apM-1; Gelatin-binding protein; gelatin-binding protein 28; unnamed protein product

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Gene Aliases: 30kDa; ACDC; ACRP30; Ad; adipo; ADIPOQ; ADIPQTL1; ADPN; APM-1; APM1; APN; GBP28

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UniProt ID: (Human) Q15848, (Mouse) Q60994

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Entrez Gene ID: (Human) 9370, (Mouse) 11450

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Function(s)
receptor binding cytokine activity hormone activity extracellular matrix structural constituent protein binding sialic acid binding identical protein binding protein homodimerization activity protein serine/threonine kinase activator activity
Process(es)
response to hypoxia positive regulation of protein phosphorylation glucose metabolic process generation of precursor metabolites and energy fatty acid beta-oxidation response to nutrient circadian rhythm response to xenobiotic stimulus response to bacterium response to sucrose response to glucose positive regulation of signal transduction gene expression negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of macrophage derived foam cell differentiation negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of cholesterol efflux regulation of glucose metabolic process response to activity fatty acid oxidation negative regulation of cell migration negative regulation of granulocyte differentiation response to nutrient levels negative regulation of protein autophosphorylation negative regulation of tumor necrosis factor production positive regulation of interleukin-8 production cellular response to insulin stimulus positive regulation of myeloid cell apoptotic process adiponectin-activated signaling pathway negative regulation of heterotypic cell-cell adhesion low-density lipoprotein particle clearance response to tumor necrosis factor glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity response to ethanol negative regulation of fat cell differentiation negative regulation of macrophage differentiation negative regulation of gluconeogenesis negative regulation of blood pressure negative regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of glucose import negative regulation of hormone secretion negative regulation of receptor-mediated endocytosis negative regulation of inflammatory response negative regulation of phagocytosis negative regulation of synaptic transmission brown fat cell differentiation response to glucocorticoid negative regulation of cholesterol import negative regulation of ERK1 and ERK2 cascade response to linoleic acid detection of oxidative stress cellular response to cAMP cellular response to xenobiotic stimulus positive regulation of monocyte chemotactic protein-1 production cellular response to epinephrine stimulus protein localization to plasma membrane negative regulation of intracellular protein transport positive regulation of cold-induced thermogenesis negative regulation of cold-induced thermogenesis positive regulation of cAMP/PKA signal transduction negative regulation of receptor binding negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration negative regulation of DNA biosynthetic process positive regulation of glycogen (starch) synthase activity positive regulation of metanephric glomerular visceral epithelial cell development positive regulation of cAMP-dependent protein kinase activity positive regulation of renal albumin absorption negative regulation of platelet-derived growth factor receptor-alpha signaling pathway negative regulation of metanephric mesenchymal cell migration positive regulation of protein kinase A signaling negative regulation of smooth muscle cell migration positive regulation of cellular protein metabolic process cellular response to drug negative regulation of low-density lipoprotein particle receptor biosynthetic process positive regulation of blood pressure positive regulation of protein kinase activity negative regulation of smooth muscle cell proliferation positive regulation of peptidyl-tyrosine phosphorylation protein homooligomerization membrane depolarization membrane hyperpolarization protein heterotrimerization
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