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PD-L1/CD274 Monoclonal Antibody (2B11D11), CoraLite® Plus 488
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FIGURE: 1 / 1
PD-L1/CD274 Antibody (CL488-66248) in IHC (PFA)
Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded human placenta tissue using CoraLite® Plus 488 PD-L1/CD274 antibody (CL488-66248, Clone: 2B11D11) at dilution of 1:200. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
CL488-66248
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2B11D11
Immunogen
PD-L1/CD274 fusion protein Ag12443
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: KDLYVVEYG SNMTIECKFP VEKQLDLAAL IVYWEMEDKN IIQFVHGEED LKVQHSSYRQ RARLLKDQLS LGNAALQITD VKLQDAGVYR CMISYGGADY KRITVKVNAP YNKINQRILV VDPVTSEHEL TCQAEGYPKA EVIWTSSDHQ VLSGKTTTTN SKREEKLFNV TSTLRINTTT NEIFYCTFRR LDPEENHTAE LVIPELPLAH PPNERTHL
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B7 homolog 1; B7-H1; B7-H1,PD-L1; CD274; CD274 antigen; costimulatory molecule; PD-L1; PDCD1 ligand 1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; programmed death-1 ligand 1; sCD274; similar to Homo sapiens B7-1 and B7-2; soluble CD274; soluble PD L1; soluble PD-L1; B7-H1; sPD L1; unnamed protein product
Gene Aliases: A530045L16Rik; B7-H; B7H1; CD274; hPD-L1; PD-L1; PDCD1L1; PDCD1LG1; PDL1; RGD1566211
UniProt ID: (Human) Q9NZQ7, (Mouse) Q9EP73
Entrez Gene ID: (Pig) 574058, (Human) 29126, (Mouse) 60533, (Rat) 499342
adaptive immune response
immune system process
negative regulation of T cell mediated immune response to tumor cell
immune response
signal transduction
cell surface receptor signaling pathway
T cell costimulation
negative regulation of interferon-gamma production
negative regulation of interleukin-10 production
positive regulation of interleukin-10 production
response to cytokine
TRIF-dependent toll-like receptor signaling pathway
positive regulation of T cell proliferation
negative regulation of T cell proliferation
positive regulation of transcription, DNA-templated
regulation of activated T cell proliferation
negative regulation of activated T cell proliferation
negative regulation of T cell activation
regulation of T cell apoptotic process
cellular response to lipopolysaccharide
negative regulation of tumor necrosis factor superfamily cytokine production
regulation of activated CD4-positive, alpha-beta T cell apoptotic process
positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process
negative regulation of CD4-positive, alpha-beta T cell proliferation
negative regulation of CD8-positive, alpha-beta T cell activation
positive regulation of cell migration
toxin transport
positive regulation of interleukin-10 secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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