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JUN Monoclonal Antibody (1G6B11), CoraLite® Plus 488

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JUN Monoclonal Antibody (1G6B11), CoraLite® Plus 488

Product Details

CL488-66313

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Flow Cytometry (Flow)

0.40 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1G6B11

Immunogen

JUN fusion protein Ag17639
View immunogen

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: PTPTQFLCPK NVTDEQEGFA EGFVRALAEL HSQNTLPSVT SAAQPVNGAG MVAPAVASVA GGSGSGGFSA SLHSEPPVYA NLSNFNPGAL SSGGGAPSYG AAGLAFPAQP QQQQQPPHHL PQQMPVQHPR LQALKE

Target Information

c-Jun is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activator protein 1; AH119; AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; cjun; enhancer-binding protein AP1; immediate early; JUN; Jun A; Jun activation domain binding protein; Jun oncogene; JUND; p39; Proto-oncogene c-Jun; proto-oncogene cJun; transcription factor AP-1; Transcription factor AP-1 subunit Jun; Transcription factor Jun; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog

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Gene Aliases: AP-1; AP1; c-Jun; cJUN; JUN; Junc; p39; Rjg-9

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UniProt ID: (Human) P05412, (Rat) P17325, (Mouse) P05627

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Entrez Gene ID: (Human) 3725, (Rat) 24516, (Mouse) 16476

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding RNA binding GTPase activator activity protein binding enzyme binding ubiquitin protein ligase binding cAMP response element binding identical protein binding ubiquitin-like protein ligase binding RNA polymerase II sequence-specific DNA binding transcription factor binding R-SMAD binding general transcription initiation factor binding sequence-specific double-stranded DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity transcription factor binding protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding poly(A) RNA binding protein heterodimerization activity HMG box domain binding basic leucine zipper transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis microglial cell activation liver development positive regulation of endothelial cell proliferation outflow tract morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process transforming growth factor beta receptor signaling pathway JNK cascade cell proliferation negative regulation of cell proliferation response to xenobiotic stimulus positive regulation of epithelial cell migration release from viral latency monocyte differentiation axon regeneration response to endoplasmic reticulum stress leading edge cell differentiation response to muscle stretch regulation of cell proliferation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of DNA binding negative regulation of neuron apoptotic process negative regulation by host of viral transcription positive regulation by host of viral transcription negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation response to steroid hormone regulation of cell cycle SMAD protein signal transduction eyelid development in camera-type eye positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion cellular response to anisomycin integrated stress response signaling positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of vascular smooth muscle cell proliferation positive regulation of DNA-templated transcription, initiation release of cytochrome c from mitochondria transcription, DNA-templated transcription from RNA polymerase II promoter SMAD protein import into nucleus aging learning circadian rhythm positive regulation of cell proliferation response to radiation response to mechanical stimulus cellular process response to organic substance response to organic cyclic compound negative regulation of protein autophosphorylation response to lipopolysaccharide response to cytokine response to drug response to hydrogen peroxide positive regulation of neuron apoptotic process positive regulation of monocyte differentiation positive regulation of DNA replication positive regulation of smooth muscle cell proliferation cellular response to potassium ion starvation response to cAMP membrane depolarization negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress cellular response to hormone stimulus positive regulation of GTPase activity positive regulation of cell differentiation
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