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Proteintech
VDAC1/Porin Monoclonal Antibody (1E2C7), CoraLite® Plus 488
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FIGURE: 1 / 1
VDAC1/Porin Antibody (CL488-66345) in Flow
1x10^6 HepG2 cells were intracellularly stained with 0.8 µg Coralite® Plus 488 Vdac1/Porin Monoclonal Antibody (CL488-66345, Clone: 1E2C7) (red), or 0.8 µg CoraLite® Plus 488-conjugated Mouse IgG3 isotype control Mouse McAb (CL488-66360-4, Clone: 1H4A5) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-66345
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG3
Class
Monoclonal
Type
Antibody
Clone
1E2C7
Immunogen
Peptide
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC constitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hVDAC1; MGC111064; Mitochondrial Porin; mVDAC1; mVDAC5; Non-selective voltage-gated ion channel VDAC1; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM; PORIN-31-HL; rVDAC1; sperm binding protein 1a; unnamed protein product; VD; VDAC-1; VDAC-5; Voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5
Gene Aliases: AL033343; PORIN; VDAC; VDAC-1; VDAC1; Vdac5
UniProt ID: (Human) P21796, (Mouse) Q60932, (Rat) Q9Z2L0
Entrez Gene ID: (Human) 7416, (Mouse) 22333, (Rat) 83529
nucleotide binding
voltage-gated ion channel activity
protein binding
ATP binding
oxysterol binding
lipid binding
voltage-gated anion channel activity
porin activity
cholesterol binding
protein kinase binding
phosphatidylcholine binding
identical protein binding
ion channel binding
ceramide binding
anion channel activity
protein complex binding
voltage-gated ion channel
behavioral fear response
ion transport
anion transport
lipid transport
apoptotic process
chemical synaptic transmission
neuron-neuron synaptic transmission
learning
epithelial cell differentiation
calcium ion transmembrane import into mitochondrion
positive regulation of apoptotic process
negative regulation of apoptotic process
transmembrane transport
anion transmembrane transport
negative regulation of calcium import into the mitochondrion
regulation of mitophagy
regulation of mitophagy
positive regulation of type 2 mitophagy
mitochondrial transmembrane transport
negative regulation of reactive oxygen species metabolic process
transport
mitochondrial calcium ion transport
regulation of anion transport
regulation of anion transmembrane transport
ion transmembrane transport
regulation of ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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