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Proteintech
SKAP2 Monoclonal Antibody (2G3G9), CoraLite® Plus 488
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Product Details
CL488-66367
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2G3G9
Immunogen
SKAP2 fusion protein Ag3615
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MPNPSSTSS PYPLPEEIRN LLADVETFVA DILKGENLSK KAKEKRESLI KKIKDVKSIY LQEFQDKGDA EDGEEYDDPF AGPPDTISLA SERYDKDDEA PSDGAQFPPI AAQDLPFVLK AGYLEKRRKD HSFLGFEWQK RWCALSKTVF YYYGSDKDKQ QKGEFAIDGY SVRMNNTLRK DGKKDCCFEI SAPDKRIYQF TAASPKDAEE WVQQLKFVLQ DMESDIIPED YDERGELYDD VDHPLPISNP LTSSQPIDDE IYEELPEEEE DSAPVKVEEQ RKMSQDSVHH TSGDKSTDYA NFYQGLWDCT GAFSDELSFK RGDVIYILSK EYNRYGWWVG EMKGAIGLVP KAYIMEMYDI
Target Information
Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fyn-associated phosphoprotein SKAP55 homologue; MGC10411; MGC33304; Pyk2/RAFTK-associated protein; Retinoic acid-induced protein 70; SKAP-55HOM; SKAP-HOM; SKAP55 homolog; SKAP55 homologue; SKAP55-HOM; src family associated phosphoprotein 2; Src family-associated phosphoprotein 2; Src kinase-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; src kinase-associated phosphoprotein of 55-related protein; Src-associated adapter protein with PH and SH3 domains; Src-associated adaptor protein; unnamed protein product
Gene Aliases: 2610021A10Rik; AA960083; BB137539; mSKAP55R; PRAP; RA70; SAPS; SCAP2; Scap55r; SKAP-HOM; SKAP2; SKAP55R
UniProt ID: (Human) O75563, (Rat) Q920G0, (Mouse) Q3UND0
Entrez Gene ID: (Human) 8935, (Pig) 100625903, (Rat) 155183, (Mouse) 54353
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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