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Proteintech
CDC37 Monoclonal Antibody (1C2A6), CoraLite® Plus 488
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Product Details
CL488-66420
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1C2A6
Immunogen
CDC37 fusion protein Ag0267
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MVDYSVWDH IEVSDDEDET HPNIDTASLF RWRHQARVER MEQFQKEKEE LDRGCRECKR KVAECQRKLK ELEVAEGGKA ELERLQAEAQ QLRKEERSWE QKLEEMRKKE KSMPWNVDTL SKDGFSKSMV NTKPEKTEED SEEVREQKHK TFVEKYEKQI KHFGMLRRWD DSQKYLSDNV HLVCEETANY LVIWCIDLEV EEKCALMEQV
Target Information
In S. cerevisiae, Cdc37 has been shown to be an important regulator of cell division cycle through its action on cyclin-dependent kinases (CDK's). Cdc37 has also been associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosine kinase. Interestingly, HSP90 has also been shown to be associated with many of the same cellular targets as Cdc37. It has now been shown that Cdc37 is the same protein previously described as p50 which has been found to be associated with many of the same proteins as HSP90. Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn, Yes, Fes, Lck & Fgr), Raf and pp60v-src. More recently, Cdc37 has been shown to be a chaperone independently and in concert with HSP90. In fact, Cdc37 is necessary for the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC 37; CDC37; CDC37 (cell division cycle 37 S. cerevisiae homolog); CDC37 (cell division cycle 37, S. cerevisiae, homolog); CDC37 cell division cycle 37 homolog; Cdc37 homolog; CDC37 protein; cell division cycle 37 homolog; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; p50Cdc37
Gene Aliases: CDC37; CDC37A; p50; P50CDC37
UniProt ID: (Human) Q16543, (Rat) Q63692, (Mouse) Q61081
Entrez Gene ID: (Human) 11140, (Rat) 114562, (Mouse) 12539
protein binding
protein kinase regulator activity
kinase binding
protein kinase binding
heat shock protein binding
unfolded protein binding
chaperone binding
Hsp90 protein binding
scaffold protein binding
protein C-terminus binding
mitogen-activated protein kinase kinase kinase binding
protein kinase B binding
chaperone
regulation of cyclin-dependent protein serine/threonine kinase activity
protein folding
protein targeting
posttranscriptional regulation of gene expression
protein stabilization
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
positive regulation of type 2 mitophagy
regulation of cell cycle
regulation of protein kinase activity
mitophagy in response to mitochondrial depolarization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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