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Proteintech
WWTR1 Monoclonal Antibody (2A12A10), CoraLite® Plus 488
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Product Details
CL488-66500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2A12A10
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MNPASAPPPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE SFFKEPDSGS HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA GAAGSPAQQH AHLRQQSYDV TDELPLPPGW EMTFTATGQR YFLNHIEKIT TWQDPRKAMN QPLNHMNLHP AVSSTPVPQR SMAVSQPNLV MNHQHQQQMA PSTLSQQNHP TQNPPAGLMS MPNALTTQQQ QQQKLRLQRI QMERERIRMR QEELMRQEAA LCRQLPMEAE TLAPVQAAVN PPTMTPDMRS ITNNSSDPFL NGGPYHSREQ STDSGLGLGC YSVPTTPEDF LSNVDEMDTG ENAGQTPMNI NPQQTRFPDF LDCLPGTNVD LGTLESEDLI PLFNDVESAL NKSEPFLTWL
Target Information
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1. In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp586I1419; FLJ27004; FLJ45718; Tafazzin; transcriptional co-activator with PDZ-binding motif; transcriptional co-activator with PDZ-binding motif (TA)Z; transcriptional co-activator with PDZ-binding motif (TAZ); transcriptional coactivator with PDZ binding motif; Transcriptional coactivator with PDZ-binding motif; unnamed protein product; WW domain-containing transcription regulator protein 1
Gene Aliases: 2310058J06Rik; 2610021I22Rik; C78399; TAZ; WWTR1
UniProt ID: (Human) Q9GZV5, (Mouse) Q9EPK5
Entrez Gene ID: (Human) 25937, (Mouse) 97064, (Rat) 295062
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
tissue homeostasis
heart process
regulation of transcription, DNA-templated
positive regulation of cell proliferation
positive regulation of epithelial to mesenchymal transition
protein ubiquitination
stem cell division
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
glomerulus development
multicellular organism growth
hippo signaling
negative regulation of fat cell differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
mesenchymal cell differentiation
cilium morphogenesis
SMAD protein signal transduction
regulation of canonical Wnt signaling pathway
kidney morphogenesis
regulation of metanephric nephron tubule epithelial cell differentiation
negative regulation of canonical Wnt signaling pathway
positive regulation of protein localization to nucleus
negative regulation of protein phosphorylation
transcription, DNA-templated
negative regulation of protein kinase activity
negative regulation of catenin import into nucleus
regulation of SMAD protein import into nucleus
regulation of nucleic acid-templated transcription
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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