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Proteintech
XRCC5 Monoclonal Antibody (2G5E7), CoraLite® Plus 488
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL488-66546
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2G5E7
Immunogen
Recombinant Protein
Conjugate
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; FLJ39089; HGNC:12833; Ku (p70/p80) subunit; Ku antigen; ku autoantigen protein p86 homolog; Ku autoantigen, 80kD); Ku autoantigen, 80kDa; Ku-80; Ku86 autoantigen related protein 1; Lupu; lupus; lupus Ku autoantigen protein p86; nuclear factor IV; OTTHUMP00000164061; OTTHUMP00000206791; thyroid-lupus autoantigen; TLAA; unnamed protein product; X-ray repair complementing defective repair in Chinese hamster cells 5; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair cross complementation (double-strand-break rejoining; X-ray repair cross complementation (double-strand-break rejoining; Ku autoantigen, 80kD); X-ray repair cross-complementing protein 5
Gene Aliases: CTC85; CTCBF; KARP-1; KARP1; KU80; Ku86; KUB2; Kup80; NFIV
UniProt ID: (Human) P13010, (Mouse) P27641
Entrez Gene ID: (Human) 7520, (Rat) 363247, (Mouse) 22596
transcription regulatory region sequence-specific DNA binding
DNA binding
DNA helicase activity
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
RNA binding
protein binding
enzyme activator activity
DNA-dependent ATPase activity
ATPase activity
ubiquitin protein ligase binding
U3 snoRNA binding
telomeric DNA binding
3'-5' DNA helicase activity
macromolecular complex binding
DNA end binding
5'-deoxyribose-5-phosphate lyase activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ATP binding
telomere maintenance
activation of innate immune response
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
telomere maintenance via telomerase
cell proliferation
response to xenobiotic stimulus
small-subunit processome assembly
negative regulation of transcription, DNA-templated
regulation of smooth muscle cell proliferation
positive regulation of neurogenesis
hematopoietic stem cell differentiation
protein localization to chromosome, telomeric region
cellular response to fatty acid
cellular hyperosmotic salinity response
cellular response to gamma radiation
cellular response to X-ray
negative regulation of t-circle formation
cellular response to leukemia inhibitory factor
recombinational repair
regulation of telomere maintenance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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