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Proteintech
Huntingtin Monoclonal Antibody (2F6C9), CoraLite® Plus 488
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Product Details
CL488-66553
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2F6C9
Immunogen
Huntingtin fusion protein Ag25922
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LDVGPEFSAS IIQMCGVMLS GSEESTPSII YHCALRGLER LLLSEQLSRL DAESLVKLSV DRVNVHSPHR AMAALGLMLT CMYTGKEKVS PGRTSDPNPA APDSESVIVA MERVSVLFDR IRKGFPCEAR VVARILPQFL DDFFPPQDIM NKVIGE
Target Information
Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HD protein; HD protein homolog; Huntingtin; Huntington disease gene homolog; Huntington disease protein; huntington disease protein homolog; unnamed protein product
Gene Aliases: AI256365; C430023I11Rik; HD; Hdh; HTT; IT15; LOMARS
UniProt ID: (Human) P42858
Entrez Gene ID: (Human) 3064, (Mouse) 15194
p53 binding
phosphoprotein phosphatase activity
protein binding
profilin binding
kinase binding
heat shock protein binding
dynactin binding
identical protein binding
ion channel binding
dynein intermediate chain binding
beta-tubulin binding
receptor binding
transcription factor binding
diazepam binding
establishment of mitotic spindle orientation
retrograde vesicle-mediated transport, Golgi to ER
apoptotic process
microtubule-based process
Golgi organization
central nervous system development
regulation of signal transduction
neurogenesis
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
protein destabilization
vocal learning
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of cilium assembly
vesicle transport along microtubule
synaptic vesicle transport
positive regulation of mitophagy
positive regulation of lipophagy
regulation of CAMKK-AMPK signaling cascade
positive regulation of CAMKK-AMPK signaling cascade
positive regulation of aggrephagy
negative regulation of extrinsic apoptotic signaling pathway
urea cycle
citrulline metabolic process
protein import into nucleus
mitochondrial transport
ER to Golgi vesicle-mediated transport
mitochondrion organization
endoplasmic reticulum organization
dopamine receptor signaling pathway
spermatogenesis
gastrulation
brain development
cell aging
learning or memory
learning
grooming behavior
locomotory behavior
axo-dendritic transport
associative learning
determination of adult lifespan
visual learning
anatomical structure morphogenesis
embryo development
anterior/posterior pattern specification
endosomal transport
lactate biosynthetic process from pyruvate
quinolinate biosynthetic process
striatum development
olfactory lobe development
neural plate formation
peptide hormone secretion
insulin secretion
regulation of protein phosphatase type 2A activity
social behavior
hormone metabolic process
negative regulation of neuron apoptotic process
regulation of mitochondrial membrane permeability
regulation of synaptic plasticity
paraxial mesoderm formation
neuron development
mRNA transport
neuron apoptotic process
response to calcium ion
regulation of mitochondrial membrane potential
L-glutamate import
iron ion homeostasis
negative regulation of neuron death
negative regulation of cysteine-type endopeptidase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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