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Proteintech
FIS1 Monoclonal Antibody (2F10E1), CoraLite® Plus 488
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Product Details
CL488-66635
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2F10E1
Immunogen
Full length FIS1 protein.
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FIS1 homolog; fission 1 (mitochondrial outer membrane) homolog; H_NH0132A01.6; hFis1; Mitochondrial fission 1 protein; mitochondrial fission molecule; tetratricopeptide repeat domain 11; Tetratricopeptide repeat protein 11; TPR repeat protein 11
Gene Aliases: CGI-135; FIS1; TTC11
UniProt ID: (Human) Q9Y3D6
Entrez Gene ID: (Human) 51024
mitochondrial fission
protein targeting to mitochondrion
apoptotic process
mitochondrion organization
response to muscle activity
peroxisome fission
response to nutrient levels
response to endoplasmic reticulum stress
positive regulation of neuron apoptotic process
mitochondrial fragmentation involved in apoptotic process
cellular response to glucose stimulus
cellular response to lipid
positive regulation of mitochondrial fission
cellular response to toxic substance
cellular response to peptide
response to fluoride
negative regulation of ATP metabolic process
response to flavonoid
response to hypobaric hypoxia
negative regulation of fatty acid transport
positive regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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