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Proteintech
ATG13 Monoclonal Antibody (1C3A7), CoraLite® Plus 488
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Product Details
CL488-66708
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C3A7
Immunogen
Recombinant Protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATG13 autophagy related 13 homolog; Autophagy-related protein 13; FLJ20698; harbinger transposase derived 1; OTTHUMP00000233321; OTTHUMP00000233322; OTTHUMP00000233323; OTTHUMP00000233324; OTTHUMP00000233325; OTTHUMP00000233326; unnamed protein product
Gene Aliases: 1110053A20Rik; ATG13; D2Ertd391e; Harbi1; Harbi1l; KIAA0652; PARATARG8; RGD1310685
UniProt ID: (Human) O75143, (Mouse) Q91YI1
Entrez Gene ID: (Human) 9776, (Pig) 100516128, (Mouse) 51897, (Rat) 362164
autophagosome assembly
mitophagy
autophagy
negative regulation of cell proliferation
positive regulation of autophagy
protein localization to pre-autophagosomal structure
piecemeal microautophagy of nucleus
regulation of cell proliferation
response to mitochondrial depolarisation
positive regulation of protein targeting to mitochondrion
mitophagy in response to mitochondrial depolarization
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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