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Proteintech
SSTR5 Monoclonal Antibody (2B10D8), CoraLite® Plus 488
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Product Details
CL488-66772
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2B10D8
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: VLYGFLSDNF RQSFQKVLCL RKGSGAKDAD ATEPRPDRIR QQQEATPPAH RAAANGLMQT SKL
Target Information
Somatostatin is a multifunctional protein affecting exocrine and endocrine protein secretion, neurotransmission, and neuronal modulation and regulating cell proliferation. All these functions of Somatostatin are executed through a class of GPCR protein family members called somatostatin receptor. Till date, 6 classes of somatostatin receptors have been discovered out of which SSTR5, 364A.A protein, is a receptor subtype expressed predominantly in the pituitary and hypothalamus region of brain. Studies revealed that SSTR5 contains seven transmembrane regions and undergoes homodimerization and also heterodimerizes with SSTR1. Although the specific functions of SSTR5 are still elusive, the studies indicate that it complements SSTR2 regulation of ACTH secretion. Polymorphisms in SSTR5 gene have been observed in patients with acromegaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: membrane receptor; SSTR5B; membrane receptor; SSTR5C; somatostatin receptor; Somatostatin receptor subtype 5; Somatostatin receptor type 5; SS-5-R; SS5-R; SS5R
Gene Aliases: Smstr5; Somato; SS-5-R; SST5; SSTR5
UniProt ID: (Human) P35346, (Mouse) O08858
Entrez Gene ID: (Human) 6755, (Rat) 25354, (Mouse) 20609
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
neuropeptide signaling pathway
negative regulation of cell proliferation
positive regulation of cytokinesis
somatostatin signaling pathway
glucose homeostasis
regulation of insulin secretion
cellular response to glucocorticoid stimulus
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
chemical synaptic transmission
cellular response to estradiol stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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