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Proteintech
HLA-F Monoclonal Antibody (1B12C2), CoraLite® Plus 488
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Product Details
CL488-66819
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B12C2
Immunogen
HLA-F fusion protein Ag6475
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: AGSHSLRYF STAVSRPGRG EPRYIAVEYV DDTQFLRFDS DAAIPRMEPR EPWVEQEGPQ YWEWTTGYAK ANAQTDRVAL RNLLRRYNQS EAGSHTLQGM NGCDMGPDGR LLRGYHQHAY DGKDYISLNE DLRSWTAADT VAQITQRFYE AEEYAEEFRT YLEGECLELL RRYLENGKET LQRADPPKAH VAHHPISDHE ATLRCWALGF YPAEITLTWQ RDGEEQTQDT ELVETRPAGD GTFQKWAAVV VPSGEEQRYT CHVQHEGLPQ PLILRWEQS
Target Information
HLA-F belongs to the HLA class I heavy chain paralogues. It is a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDA12; HLA class I histocompatibility antigen, alpha chain F; HLA F antigen; HLA-F; Leukocyte antigen F; MHC class I antigen F; non-classical; non-classical MHC class I antigen; nonclassical MHC class I antigen; unnamed protein product
Gene Aliases: CDA12; HLA-5.4; HLA-CDA12; HLA-F; HLAF
UniProt ID: (Human) P30511
Entrez Gene ID: (Human) 3134
positive regulation of T cell mediated cytotoxicity
immune system process
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
antigen processing and presentation of exogenous peptide antigen via MHC class Ib
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
negative regulation of T cell cytokine production
negative regulation of natural killer cell cytokine production
positive regulation of natural killer cell cytokine production
immune response
negative regulation of natural killer cell degranulation
positive regulation of natural killer cell degranulation
negative regulation of natural killer cell mediated cytotoxicity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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