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Proteintech
OGT Monoclonal Antibody (2B2A6), CoraLite® Plus 488
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL488-66823
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2B2A6
Immunogen
OGT fusion protein Ag28402
Conjugate
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: MASSVGNVAD STGLAELAHR EYQAGDFEAA ERHCMQLWRQ EPDNTGVLLL LSSIHFQCRR LDRSAHFSTL AIKQNPLLAE AYSNLGNVYK ERGQLQEAIE HYRHALRLKP DFIDGYINLA AALVAAGDME GAVQAYVSAL QYNPDLYCVR SDLGNLLKAL GRLEEAKACY LKAIETQPNF AVAWSNLGCV FNAQGEIWLA IHHFEKAVTL DPNFLDAYIN LGNVLKEARI FDRAVAAYLR ALSLSPNHAV VHGNLACVYY EQGLIDLAID TYRRAIELQP HFPDAYCNLA NALKEKGSVA EAEDCYNTAL RLCPTHADSL NNLANIKREQ GNIEEAVRLY RKALEVFPEF AAAHSNLASV LQQQGKLQEA LMHYKEAIRI SPTFADAYSN MGNTLKEMQD
Target Information
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ23071; MGC22921; O linked N-acetylglucosamine transferase; o-glcnac transferase; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; UDP-N-acetylglucosamine:polypeptide-N- acetylglucosaminyl transferase; UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
Gene Aliases: 1110038P24Rik; 4831420N21Rik; AI115525; OGT; Ogtl
UniProt ID: (Pig) Q27HV0, (Mouse) Q8CGY8, (Rat) P56558
Entrez Gene ID: (Pig) 664652, (Mouse) 108155, (Rat) 26295
phosphatidylinositol-3,4,5-trisphosphate binding
protein N-acetylglucosaminyltransferase activity
histone acetyltransferase activity (H4-K5 specific)
histone acetyltransferase activity (H4-K8 specific)
histone acetyltransferase activity (H4-K16 specific)
protein O-GlcNAc transferase activity
catalytic activity
protein binding
enzyme activator activity
N-acetyltransferase activity
transcription factor binding
lipid binding
transferase activity
transferase activity, transferring glycosyl groups
protein domain specific binding
peptide binding
monosaccharide binding
protein modifying enzyme
regulation of glycolytic process
regulation of gluconeogenesis
protein O-linked glycosylation
apoptotic process
protein processing
negative regulation of protein ubiquitination
circadian regulation of gene expression
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
positive regulation of proteolysis
positive regulation of transcription from RNA polymerase II promoter
phosphatidylinositol-mediated signaling
positive regulation of histone H3-K27 methylation
histone H3-K4 trimethylation
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
glucosamine metabolic process
positive regulation of gene expression
negative regulation of peptidyl-threonine phosphorylation
chromatin modification
positive regulation of granulocyte differentiation
response to insulin
negative regulation of peptidyl-serine phosphorylation
regulation of Rac protein signal transduction
positive regulation of catalytic activity
positive regulation of cell size
regulation of insulin receptor signaling pathway
intracellular distribution of mitochondria
rhythmic process
positive regulation of histone H3-K4 methylation
negative regulation of cell death
protein homotrimerization
protein heterotrimerization
cellular response to lipopolysaccharide
cellular response to retinoic acid
cellular response to glucose stimulus
negative regulation of protein targeting to membrane
regulation of gluconeogenesis involved in cellular glucose homeostasis
negative regulation of cellular response to hypoxia
positive regulation of protein localization to nucleus
positive regulation of reactive oxygen species biosynthetic process
forebrain development
cellular response to insulin stimulus
cellular response to toxic substance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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